ReviveAI

SCALEX Clinical Gate

Authorized clinical operators only. Access is strictly audited under HIPAA guidelines.

ReviveAI

ReviveAI: Large Scalable Vector Embeddings (SCALEX) for Drug Repurposing

System Active
THEME: ALBION
Role: Clinical Lead

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Curated Drugs
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Target Diseases
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Protein Targets
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Network Edges

Curated Database Records FDA & DrugBank

Drug Name Protein Target Gene Identifier Primary Disease Group
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Curation Methodology

This dataset is constructed by programmatically aggregating, normalising, and mapping entries across the following biological resources using Python standard library scripts:

  • ChEMBL Client API: Programmatic filters targeting compounds with a clinical Phase 4 status.
  • DrugBank Scraping: Target protein sequence lists and molecular descriptions matching specific biological clusters.
  • DisGeNET Scrapers: Text-mined genomic associations linking diseases directly to therapeutic indications.
  • openFDA: Event report indications and generic labeling parameters.

Data Preprocessing Applied

Consistent naming conventions are standardized to HGNC for genes, MeSH/UMLS for diseases, and UniProt for protein sequences to prevent graph entity duplication.

Molecular Knowledge Graph

Interactive 2-hop topological network visualization. Click nodes to focus the network around its local molecular signaling environment.

Network Topologies

Topological Edge Legends

Drug-Target Interaction (Forest Green)
Target-Disease Association (Terracotta)
Known Therapeutic Link (Gold)
Target-Pathway Membership (Brown)

Heterogeneous Graph Embedding

Graph embeddings are derived using a 2-layer HeteroGCN architecture. In contrast to flat vectors, structural relationships are preserved via translating translation vectors (BiTrans Aggregation) representing complex pharmacological relationships.

Repositioning Inference

Select a target drug and disease. The ReviveAI dual-stage network will query semantic biomedical literature representations and combine them with topological graph embeddings.

Log Clinical Decision (Mem0)

Persist clinical evaluations, trial outcomes, or compliance warnings directly into local Mem0 semantic database.

ReviveAI Model Explanation

Repurposing Score (Prob) --
Evaluation Status: N/A

Active Mapped Targets

N/A

Multiple Instance Learning (MIL) Attention

LLM Prompt & Vocab Logits Generated

Query Prompt: --

5-Fold Cross-Validation Monitor Idle

Real-time loss developments and model metrics tracked across k-fold structural partitions. Known therapeutic links under test are removed dynamically to prevent data leaks.

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Epoch
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Loss
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Val AUROC
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Val AUPR

GNN + LLM Configuration

[System] Ready to trigger ReviveAI training workflow.